The Three Main GLP-1 Medications
Three GLP-1-based medications dominate the weight loss market: semaglutide (Ozempic/Wegovy), tirzepatide (Mounjaro/Zepbound), and liraglutide (Saxenda). Each works differently, produces different results, and comes at a different price point. Understanding these differences is key to choosing the right treatment. Learn more about how GLP-1 medications work.
Tirzepatide: The Most Effective
Clinical data consistently shows tirzepatide produces the greatest weight loss — up to 22.5% of body weight in the SURMOUNT trials. As a dual-agonist targeting both GLP-1 and GIP receptors, it has a broader metabolic effect. Available as Mounjaro (diabetes) and Zepbound (weight loss). See our Zepbound vs Wegovy comparison.
Semaglutide: The Most Established
Semaglutide is the most widely used GLP-1 for weight loss, with the longest track record and broadest availability through telehealth providers. The STEP trials showed ~15% average weight loss. Available as brand-name (Ozempic, Wegovy) and compounded versions. Compare semaglutide providers.
Liraglutide: The Third Option
Liraglutide (Saxenda) was the first GLP-1 approved specifically for weight loss. It produces more modest results (~5-8% body weight) compared to semaglutide and tirzepatide, and requires daily rather than weekly injections. It's less commonly prescribed now but remains an option for patients who don't respond well to other GLP-1s.
What To Know Before Starting GLP-1 Treatment
Before starting GLP-1 treatment, it's important to understand a few key things. These medications require a prescription from a licensed clinician and aren't suitable for everyone. Some people may experience side effects, especially during the first few weeks as the body adjusts.
GLP-1s also tend to work best when combined with basic lifestyle habits like balanced nutrition and regular physical activity.
That's why choosing a provider that offers proper medical screening and ongoing follow-up support is essential for both safety and long-term success.
Cost Comparison
Brand-name costs: Wegovy $1,300+/month, Zepbound $1,000+/month, Saxenda $1,300+/month. Compounded versions are significantly cheaper — semaglutide from ~$199/month and tirzepatide from ~$349/month. See our semaglutide cost breakdown and full cost guide.
Which Should You Choose?
For maximum weight loss: tirzepatide. For the most established option with widest availability: semaglutide. For patients who prefer or need an alternative: liraglutide. Your provider can help determine which is best based on your health profile. Take our quiz to find a provider that offers the medication best suited to your goals.